| A new generation templated mesoporous bioactive glasses (MBGs) with alkali oxide has been synthesized for
biomedical applications with different compositions by sol-gel method. The sol-gel route involves the evaporation
induced self assembly (EISA) process using non-ionic block copolymer as structure directing agent. In vitro
bioactivity test on the obtained glasses after immersion in simulated body fluid has been carried out for various
time durations. With the aid of four different glass systems, the role of calcium and phosphorus on in vitro bioactivity
of silicate glasses has been investigated. Several analytical techniques have been used to characterize the MBG
samples before and after soaking in the simulated body fluid (SBF) to establish correlation between composition,
porosity and bioactivity. The quaternary glasses have been found to show rapid hydroxycarbonate apatite (HCA)
formation and crystallization than ternary and binary glasses independent of Na2O/CaO content. Based on the
obtained results, it has been suggested that the presence of phosphorous and calcium in the bioglass appreciably
increases the rate of apatite crystallization.
[Keywords: Bioactive glass, Mesoporous, Biocompatibility, Biodegradation] |
