| Zirconia Enriched BaO-SiO2
-TiO2
Glasses with Enhanced
Physical, Mechanical and Biological Performances |
Rajat Kumar Mishra,a
Rahul Singh,a
Sarvesh Kumar Avinashi,a
Shweta,a
Akash Sachan,a
Shama
Parveen,b
Amreen Shamsad,b
Surajita Sahu,c
Saurabh Kumar,b
Savita Kumari,a
Zaireen Fatima,a
Monalisa Mishra,c
Monisha Banerjeeb
and Chandkiram Gautama,*
Pages : 272-282
DOI: 10.1080/0371750X.2025.2584810 |
| Abstract |
| Zirconia doped glasses are ideal for biomedical applications owing to their improved
mechanical strength, non-toxicity and biocompatibility. Herein, ZrO2
doped BaO-SiO2
-
TiO2
(BST) based glasses within the system (30–x)BaO.40SiO2
.30TiO2
.xZrO2
(06)
were fabricated using a melt-quenching technique. X-ray diffraction (XRD) measurements
confirmed the non-crystalline nature of the glass samples. Density of the glasses
increased from 3.538 to 3.802 g/cm3
. Fourier transform infrared (FTIR) spectroscopy
was employed to examine the structural or bonding mechanism. Further, mechanical
performance of the glass pellets was studied using a universal testing machine (UTM)
in compression mode, showing that the compressive strength increased with higher
ZrO2
content, from 20.4 to 222 MPa of the glasses. Cell viability using 3-(4,5-dimethyl-2-
yl)-2,5-diphenyltetrazolium bromide (MTT) assays on the human osteoblastic cell line
(MG-63) revealed no cytotoxic effects on osteoblast cells, and maintaining cell viability
even at higher concentrations. Additionally, cell cytotoxicity was evaluated using trypan
blue assay and DAPI (4,6-diamidino-2-phenylindole) staining on glass samples.
Therefore, the present study uniquely demonstrates that systematic ZrO2
incorporation
into BaO-SiO2
-TiO2
glass matrices markedly enhances both mechanical strength and
biological activity, establishing a new class of bioactive glass compositions with
simultaneous structural and biomedical advantages for bone regeneration applications.
[Keywords: Glasses, X-ray diffraction, FTIR spectroscopy, Young’smodulus, Cellviability] |
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